FEATURES

FAMILY

class-I aminoacyl-tRNA synthetase family

DESCRIPTION

Also known as SYW2_DEIRA, trpS2, trpSII. Catalyzes the formation of 5'adenyl-Trp and tRNA(Trp) but with 5-fold less activity than TrpRS. Increases the solubility of the nitric oxide synthase oxygenase (nos), as well as its affinity for substrate L-arginine and its nitric-oxide synthase activity. The complex between trpS2 and nos catalyzes the regioselective nitration of tryptophan at the 4-position. Homodimer. Forms a complex with nos; one homodimer of trpS2 binds one homodimer of nos.

EXTERNAL LINKS

uniprot
enzyme classification

trpS2

Mutations

Mutation(s) distribution

Mutations table