FEATURES

FAMILY

DESCRIPTION

Also known as RAF2B_ARATH, RABF2B, ARA-7, RAB5B. Endosomal protein that may be involved in endocytosis (PubMed:16103374). Involved in the trafficking of proteins from prevacuolar compartments (PVCs) to vacuoles (PubMed:23682115, PubMed:24824487). May activate the MON1-CCZ1 complex which acts as guanine nucleotide exchange factors (GEF) for Rab7 protein family, and serves as a link between Rab5 and Rab7 families in PVCs, and mediates PVC maturation (PubMed:24824487). Involved in vacuolar transport of storage proteins with EREX as effector. Regulates membrane trafficking to protein storage vacuoles (PSVs) (PubMed:27288222). Interacts with VPS9A homodimer (PubMed:18055610, PubMed:20833725). Interacts with TCTP1 (PubMed:20736351). Interacts with MON1 (PubMed:24824487). Interacts with EREX (via PX domain) (PubMed:27288222). Binds to VPS3 (PubMed:29463724).

EXTERNAL LINKS

RABF2B

Mutations

Mutation(s) distribution

Mutations table