FEATURES

DESCRIPTION

Also known as EDS1C_ARATH, EDS1, EDS1-90, EDS1A. Positive regulator of basal resistance and of effector-triggered immunity specifically mediated by TIR-NB-LRR (TNL) resistance proteins. Disruption by bacterial effector of EDS1-TIR-NB-LRR resistance protein interactions constitutes the first step in resistance activation (PubMed:22158819). Acts redundantly with salicylic acid to regulate resistance gene-mediated signaling (PubMed:19578402). Triggers early plant defenses and hypersensitive response independently of PAD4, and then recruits PAD4 to potentiate plant defenses through the accumulation of salicylic acid (PubMed:11574472). Nuclear localization is essential for basal and TNL-conditioned immunity and for reprogramming defense gene expression, while cytoplasmic EDS1 is required to induce a complete immune response (PubMed:20617163). Heterodimerization with PAD4 and/or SGA101 is necessary for TNL-mediated effector-triggered immunity (PubMed:24331460). Contributes to nonhost resistance against E.amylovora (PubMed:22316300). Loss of EDS1-PAD4 interaction compromises basal but not TNL-triggered resistance (PubMed:21434927). Necessary for systemic acquired resistance (SAR) signal generation and perception (PubMed:24755512). Has no direct lipase activity (PubMed:16040633). Putative lipase activity is dispensable for immune functions (PubMed:24331460). Homodimer (PubMed:11574472, PubMed:22158819). Interacts with RPS4, RPS6, SNC1, SRFR1, AvrRps4 and HopA1 (PubMed:22158818, PubMed:22158819). Part of a nuclear complex made of EDS1, PAD4 and SAG101, that can be redirected to the cytoplasm in the presence of an extranuclear form of EDS1 (PubMed:22072959).Interacts (via N-terminus) with PAD4 (via N-terminus) (PubMed:11574472, PubMed:21434927, PubMed:22072959). Interacts (via N-terminus) with SAG101 (PubMed:16040633, PubMed:21434927, PubMed:22072959). EDS1-SAG101 and EDS1-PAD4 form separate complexes in pathogen-unchallenged cells (PubMed:16040633, PubMed:21434927). Part of a nuclear protein complex made of VICTR, PAD4 and EDS1 (PubMed:23275581). Interacts with VICTR (PubMed:23275581).

EXTERNAL LINKS

EDS1

Protein EDS1

Mutations

Mutation(s) distribution

Mutations table

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