FEATURES

FAMILY

DESCRIPTION

Also known as ORC3_HUMAN, ORC3, LATHEO, ORC3L. Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.

EXTERNAL LINKS

ORC3

Origin recognition complex subunit 3

Structural Ligandability

Domains Chains

0 chains assessed

1 chain not associated with a domain

ORC3

Structural Ligandability

Domains Chains

Distribution