FEATURES

FAMILY

DESCRIPTION

Also known as CLCF1_HUMAN, CLCF1, BSF3, CLC, NNT1. In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). Also stimulates B-cells. Binds to and activates the ILST/gp130 receptor. Forms a heteromeric complex with cardiotrophin-like cytokine CRLF1/CLF-1; the CRLF1-CLCF1 complex is a ligand for the ciliary neurotrophic factor receptor/CNTFR (PubMed:26858303). The CRLF1-CLCF1 heterodimer binds SORL1 (via N-terminal ectodomain); within this complex, the interaction is mediated predominantly by the CRLF1 moiety (PubMed:26858303). The tripartite signaling complex formed by CRLF1, CLCF1 and CNTFR also binds SORL1 (PubMed:26858303).

Also known as CLCF1_HUMAN, CLCF1, BSF3, CLC, NNT1. In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). Also stimula ...

EXTERNAL LINKS

CLCF1

Cardiotrophin-like cytokine factor 1

CLCF1

Molecular Synopsis