FEATURES

FAMILY

DESCRIPTION

Also known as I36RA_HUMAN, IL36RN, FIL1D, IL1F5, IL1HY1, IL1L1, IL1RP3. Inhibits the activity of interleukin-36 (IL36A, IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion.

Also known as I36RA_HUMAN, IL36RN, FIL1D, IL1F5, IL1HY1, IL1L1, IL1RP3. Inhibits the activity of interleukin-36 (IL36A, IL36B and IL36G) by binding to receptor IL1RL2 and preventing its associat ...

EXTERNAL LINKS

IL36RN

Mutations

Mutation(s) distribution

Mutations table