FEATURES

FAMILY

DESCRIPTION

Also known as P2RX2_HUMAN, P2RX2, P2X2. Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle. Homotrimer and heterotrimer; functional P2XRs are organized as homomeric and heteromeric trimers.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

P2RX2

P2X purinoceptor 2

P2RX2

Molecular Synopsis