FEATURES

FAMILY

DESCRIPTION

Also known as POLK_HUMAN, POLK, DINB1. DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Interacts with REV1 (By similarity). Interacts with PCNA (PubMed:11784855).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

POLK

Mutations

Mutation(s) distribution

Mutations table