FEATURES

DESCRIPTION

Also known as DBF4A_HUMAN, DBF4, ASK, DBF4A, ZDBF1. Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. Forms a complex with CDC7. Note that CDC7 forms distinct complex either with DBF4A or DBF4B. Such complexes are stable upon replication stress. Interacts with MEN1, MCM2, ORC2, ORC4 and ORC6. Interacts (via IBM motifs) with PSIP1 (via IBD domain); phosphorylation increases its affinity for PSIP1 (PubMed:29997176).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DBF4

Protein DBF4 homolog A

DBF4

Molecular Synopsis