FEATURES

FAMILY

DESCRIPTION

Also known as KLOT_HUMAN, KL. May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity)., The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling. Homodimer. Interacts with FGF23 and FGFR1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

KL

Klotho

KL

Molecular Synopsis