FEATURES

DESCRIPTION

Also known as TRPS1_HUMAN, TRPS1. Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. Interacts with RNF4; regulates TRPS1 repressor activity. Interacts specifically with the activator form of GLI3 (GLI3A) but not with the repressor form (GLI3R).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TRPS1

Zinc finger transcription factor Trps1

TRPS1

Molecular Synopsis