FEATURES

FAMILY

L-type amino acid transporter (LAT) (TC 2.A.3.8) family

DESCRIPTION

Also known as LAT2_HUMAN, SLC7A8, LAT2. Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D, L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney. Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.

Also known as LAT2_HUMAN, SLC7A8, LAT2. Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine ...

EXTERNAL LINKS

SLC7A8

Mutations

Mutation(s) distribution

Mutations table