FEATURES

FAMILY

DESCRIPTION

Also known as CEIP2_HUMAN, CEMIP2, KIAA1412, TMEM2. Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 5 kDa fragments (PubMed:28246172). Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling (By similarity). Is very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate (PubMed:28246172).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CEMIP2

Cell surface hyaluronidase

CEMIP2

Molecular Synopsis