FEATURES

FAMILY

Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family

DESCRIPTION

Also known as NCKX2_HUMAN, SLC24A2, NCKX2. Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SLC24A2

Sodium/potassium/calcium exchanger 2

SLC24A2

Molecular Synopsis