FEATURES

FAMILY

DESCRIPTION

Also known as KIF25_HUMAN, KIF25, KNSL3. Minus-end microtubule-dependent motor protein (By similarity). Acts as a negative regulator of centrosome separation required to prevent premature centrosome separation during interphase (PubMed:28263957). Required to maintain a centered nucleus to ensure that the spindle is stably oriented at the onset of mitosis (PubMed:28263957). May also act as a negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). Homotetramer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

KIF25

Kinesin-like protein KIF25

KIF25

Molecular Synopsis