FEATURES

FAMILY

DESCRIPTION

Also known as HACL1_HUMAN, HACL1, HPCL, HPCL2, PHYH2. Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner (PubMed:28289220, PubMed:21708296, PubMed:10468558). Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids (PubMed:28289220, PubMed:21708296, PubMed:10468558). Plays a significant role in the biosynthesis of heptadecanal in the liver (By similarity). Homotetramer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

HACL1

2-hydroxyacyl-CoA lyase 1

HACL1

Molecular Synopsis