FEATURES

FAMILY

DESCRIPTION

Also known as KCNE5_HUMAN, KCNE5, AMMECR2, KCNE1L. Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1. Interacts with KCNQ1; impairs KCNQ1 localization in lipid rafts and only conducts current upon strong and continued depolarization.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

KCNE5

Potassium voltage-gated channel subfamily E regulatory beta subunit 5

KCNE5

Molecular Synopsis