FEATURES

FAMILY

CDP-alcohol phosphatidyltransferase class-I family

DESCRIPTION

Also known as CRLS1_HUMAN, CRLS1, C20orf155, CLS1. Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CRLS1

Cardiolipin synthase (CMP-forming)

CRLS1

Molecular Synopsis