FEATURES

FAMILY

DESCRIPTION

Also known as UBP21_HUMAN, USP21, USP23. Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (PubMed:10799498). Deubiquitinates BAZ2A/TIP5 leading to its stabilization (PubMed:26100909). Interacts with BEND3 and BAZ2A/TIP5.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

USP21

Ubiquitin carboxyl-terminal hydrolase 21

USP21

Molecular Synopsis