FEATURES

FAMILY

DESCRIPTION

Also known as ZHX1_HUMAN, ZHX1. Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins. Forms homodimers. Heterodimer (via HD1 domain) with ZHX2 (via HD1 domain). Also forms a heterodimer with ZHX3 which is a prerequisite for repressor activity. Interacts with ATF7IP and NFYA. Interacts (via homeobox domains) with DNMT3B (via PWWP domain).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ZHX1

Zinc fingers and homeoboxes protein 1

ZHX1

Molecular Synopsis