FEATURES

FAMILY

DESCRIPTION

Also known as MTUS1_HUMAN, MTUS1, ATBP, ATIP, GK1, KIAA1288, MTSG1. Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. Homodimer. Interacts with AGTR2. Interacts with PTPN6 (By similarity). Isoform 1 associates with microtubules.

Also known as MTUS1_HUMAN, MTUS1, ATBP, ATIP, GK1, KIAA1288, MTSG1. Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. To ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MTUS1

Microtubule-associated tumor suppressor 1

MTUS1

Molecular Synopsis