FEATURES

FAMILY

DESCRIPTION

Also known as HECD1_HUMAN, HECTD1, KIAA1131. E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion. Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure. Interacts with IGSF1 (PubMed:12421765). Interacts (via N-terminus) with HSP90AA1 (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

HECTD1

E3 ubiquitin-protein ligase HECTD1

HECTD1

Molecular Synopsis