FEATURES

FAMILY

DESCRIPTION

Also known as MGT4A_HUMAN, MGAT4A. Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MGAT4A

Alpha-1, 3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

MGAT4A

Molecular Synopsis