FEATURES

DESCRIPTION

Also known as GUC1B_HUMAN, GUCA1B, GCAP2. Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated (By similarity). This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor response and recovery of response in bright light (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GUCA1B

Guanylyl cyclase-activating protein 2

GUCA1B

Molecular Synopsis