FEATURES

FAMILY

DESCRIPTION

Also known as S12A4_HUMAN, SLC12A4, KCC1. Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity. Homomultimer and heteromultimer with other K-Cl cotransporters.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SLC12A4

Solute carrier family 12 member 4

Mutations

Mutation(s) distribution

Mutations table

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