FEATURES

FAMILY

DESCRIPTION

Also known as ARIS_ASPTE, Ari1. Catalyzes the cyclization of trans, trans-farnesyl diphosphate (FPP) to the bicyclic sesquiterpene aristolochene. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce aristolochene. Aristolochene is the likely parent compound for a number of sesquiterpenoid toxins produced by filamentous fungi. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

Ari1

Aristolochene synthase

Ari1

Molecular Synopsis