FEATURES

FAMILY

DESCRIPTION

Also known as TDRKH_DROME, papi, Tdrd2. Involved in the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons which is essential for germline integrity (PubMed:21447556, PubMed:29531043). Likely to act by recruiting Piwi proteins such as AGO3 and piwi to the piRNA biogenesis machinery in the nuage (PubMed:21447556, PubMed:29531043). Required for the final steps of primary piRNA biogenesis by participating in the 3' end-trimming of piwi-bound intermediates into mature piRNAs (PubMed:29531043). Interacts (via C-terminus) with AGO3 (via the N-terminal region when symmetrically methylated on arginine residues); this interaction is RNA-independent and may be required for AGO3 localization to the nuage (PubMed:21447556). Interacts (via Tudor domain) with piwi (via N-terminus) (PubMed:21447556, PubMed:29531043). Interacts with tral and me31B (PubMed:21447556).

EXTERNAL LINKS

papi

Tudor and KH domain-containing protein homolog

papi

Molecular Synopsis