FEATURES

FAMILY

DESCRIPTION

Also known as AGO2_DROME, AGO2. Essential for RNA interference (RNAi); double-stranded RNA induces potent and specific gene silencing (PubMed:11498593, PubMed:12368261, PubMed:14508492, PubMed:32504809). RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger (PubMed:11498593, PubMed:12368261, PubMed:14508492). Interacts with Fmr1, Dcr-1 and vig to form the RNA-induced silencing complex (RISC), a ribonucleoprotein (RNP) complex involved in translation regulation, other components of the complex are RpL5, RpL11 and Rm62 (PubMed:11498593, PubMed:14508492, PubMed:12368261). As part of the RISC complex, interacts with Tudor-SN (PubMed:14508492).

EXTERNAL LINKS

AGO2

Protein argonaute-2

AGO2

Molecular Synopsis