FEATURES

DESCRIPTION

Also known as PANX_DROME, Panx. Acts via the piwi-interacting RNA (piRNA) pathway which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:26472911, PubMed:26494711). Required for transcriptional silencing of transposons targeted by piwi and confers its effects by interacting with nascent RNA transcripts (PubMed:26472911, PubMed:26494711). Likely to be recruited to nascent transcripts cotranscriptionally by piwi and to recruit additional factors involved in transcriptional silencing (PubMed:26472911). In the ovaries, forms a complex with nxf2, piwi and Nxt1 which acts as effectors of cotranscriptional transposon silencing (PubMed:31219034, PubMed:31368590, PubMed:31570835, PubMed:31384064). The interaction with nxf2 stabilizes the nuclear protein complex (PubMed:31384064). In the ovaries, part of a complex composed of at least Panx, nxf2, piwi and Nxt1 (PubMed:26472911, PubMed:26494711, PubMed:31570835, PubMed:31219034, PubMed:31368590, PubMed:31384064). The complex is knowns as Panx-induced cotranscriptional silencing (PICTS) complex, Panx-nxf2-dependent TAP/p15 silencing (Pandas complex), SFiNX (silencing factor interacting nuclear export variant) or piwi-Panx-nxf2-p15 (PPNP) complex (PubMed:26472911, PubMed:26494711, PubMed:31570835, PubMed:31219034, PubMed:31368590, PubMed:31384064). Interacts (via NIR region) with nxf2 (via TAP-C domain); the interaction is direct (PubMed:31368590, PubMed:31219034, PubMed:31570835, PubMed:31384064).

EXTERNAL LINKS

Panx

Protein panoramix

Panx

Molecular Synopsis