FEATURES

FAMILY

DESCRIPTION

Also known as TRPV2_MOUSE, Trpv2, Grc. Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with SLC50A1; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation (By similarity).

Also known as TRPV2_MOUSE, Trpv2, Grc. Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide hea ...

EXTERNAL LINKS

Trpv2

Transient receptor potential cation channel subfamily V member 2

Mutations

Mutation(s) distribution

Mutations table

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