FEATURES

FAMILY

Cation-independent O-methyltransferase family

DESCRIPTION

Also known as MMCR_STRLA, mmcR. Involved in the biosynthesis of the quinone methoxy group present in the mitomycin A and B, which are used as anticancer agents (PubMed:10099135, PubMed:17461583). In vitro, catalyzes the 6-O-methylation of both C9-beta- and C9-alpha-configured 6-hydroxymitomycins via the transfer of the S-methyl group of S-adenosyl-L-methionine (AdoMet) to the 6-demethylmitomycin A and B. It can also use hydroxyquinone as substrate (PubMed:17461583). Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

mmcR

Mitomycin biosynthesis 6-O-methyltransferase

mmcR

Molecular Synopsis