FEATURES

FAMILY

DESCRIPTION

Also known as DNAL1_CHLRE, LC1. Part of the multisubunit axonemal ATPase complexes that generate the force for flagellar motility and govern beat frequency (PubMed:19620633). Component of the outer arm dynein (ODA) (PubMed:19620633). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (ODA2) to the A-tubule of the outer doublet microtubules within the axoneme (PubMed:22157010, PubMed:10353837, PubMed:19620633). Interacts with OCAD2, a outer arm dynein heavy chain (PubMed:19620633, PubMed:22157010). Interacts with tubulin (previously called p45) located within the A-tubule of the outer doublets in a ATP-independent manner (PubMed:19620633, PubMed:10876244, PubMed:22157010).

EXTERNAL LINKS

LC1

Mutations

Mutation(s) distribution

Mutations table