FEATURES

FAMILY

DESCRIPTION

Also known as TRPC6_HUMAN, TRPC6, TRP6. Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. Homodimer; forms channel complex (PubMed:26892346). Interacts with MX1 and RNF24 (PubMed:15757897, PubMed:17850865).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TRPC6

Short transient receptor potential channel 6

TRPC6

Molecular Synopsis