FEATURES

FAMILY

DESCRIPTION

Also known as DMTF1_HUMAN, DMTF1, DMP1. Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1. Interacts with the D-type cyclins CCND1, CCND2 and CCND3. Interaction with D-type cyclins may modulate transcriptional activation by this protein.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DMTF1

Cyclin-D-binding Myb-like transcription factor 1

DMTF1

Molecular Synopsis