FEATURES

FAMILY

cyclic nucleotide phosphodiesterase family

DESCRIPTION

Also known as PDE10_HUMAN, PDE10A. Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PDE10A

cAMP and cAMP-inhibited cGMP 3', 5'-cyclic phosphodiesterase 10A

Structural Ligandability

Domains Chains

0 chains assessed

1 chain not associated with a domain

PDE10A

Structural Ligandability

Domains Chains

Distribution