FEATURES

FAMILY

DESCRIPTION

Also known as SIA10_HUMAN, ST3GAL6, SIAT10. Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2, 3-sialyltransferase activity toward Gal-beta1, 4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1, 4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ST3GAL6

Type 2 lactosamine alpha-2, 3-sialyltransferase

ST3GAL6

Molecular Synopsis