FEATURES

DESCRIPTION

Also known as E41L3_HUMAN, EPB41L3, DAL1, KIAA0987. Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. Interacts (via FERM domain) with CADM1 (PubMed:12234973, PubMed:21131357). Interacts (via FERM domain) with PRMT3; the interaction is direct and inhibits the protein-arginine N-methyltransferase activity of PRMT3 (PubMed:15334060). Interacts with PRMT5 (PubMed:15334060, PubMed:15737618). Interacts with PRMT6 (PubMed:15334060).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

EPB41L3

Mutations

Mutation(s) distribution

Mutations table