FEATURES

FAMILY

DESCRIPTION

Also known as STB5L_HUMAN, STXBP5L, KIAA1006, LLGL4. Plays a role in vesicle trafficking and exocytosis inhibition. In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane. Plays also a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation (By similarity). Promotes as well axonal outgrowth (PubMed:25504045). Interacts with STX1A and STX4.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

STXBP5L

Syntaxin-binding protein 5-like

STXBP5L

Molecular Synopsis