FEATURES

FAMILY

DESCRIPTION

Also known as NOP58_HUMAN, NOP58, NOL5, NOP5. Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles; the core proteins SNU13, NOP56, NOP58 and FBL assemble stepwise onto the snoRNA. Interacts with NOLC1/Nopp140. Interacts with NOPCHAP1, NUFIP1, RUVBL1 and RUVBL2; NOPCHAP1 bridges the association of NOP58 with RUVBL1:RUVBL2 and NUFIP1 (PubMed:33367824). Interacts with PIH1D1 (PubMed:17636026).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NOP58

Nucleolar protein 58

NOP58

Molecular Synopsis