FEATURES

FAMILY

archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family

DESCRIPTION

Also known as RPC10_HUMAN, POLR3K, RPC11. DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.

EXTERNAL LINKS

POLR3K

Mutations

Mutation(s) distribution

Mutations table