FEATURES

FAMILY

DESCRIPTION

Also known as FIS1_HUMAN, FIS1, TTC11. Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. Interacts with DNM1L/DLP1 through the TPR region. Interacts with MARCHF5. Interacts with MIEF1. Interacts with PEX11A, PEX11B and PEX11G (PubMed:20826455).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FIS1

Mitochondrial fission 1 protein

FIS1

Molecular Synopsis