FEATURES

FAMILY

Classic translation factor GTPase family

DESCRIPTION

Also known as HBS1L_HUMAN, HBS1L, HBS1, KIAA1038. Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway (PubMed:21448132). In the presence of ABCE1 and PELO, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes (PubMed:21448132). Together with PELO and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway (PubMed:21448132)., Facilitates the association of the exosome complex with the SKI complex. Interacts with the SKI complex.

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EXTERNAL LINKS

HBS1L

HBS1-like protein

ligandability Mutations

HBS1L

Molecular Synopsis