FEATURES

FAMILY

DESCRIPTION

Also known as ATG4B_HUMAN, ATG4B, APG4B, AUTL1, KIAA0943. Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ATG4B

Cysteine protease ATG4B

ATG4B

Molecular Synopsis