FEATURES

FAMILY

DESCRIPTION

Also known as BACE2_HUMAN, BACE2, AEPLC, ALP56, ASP21. Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (PubMed:21907142). Monomer. Interacts ith RTN3 and RTN4.

Also known as BACE2_HUMAN, BACE2, AEPLC, ALP56, ASP21. Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to th ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

BACE2

Beta-secretase 2

BACE2

Molecular Synopsis