FEATURES

FAMILY

DESCRIPTION

Also known as TRUA_HUMAN, PUS1. Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 RNA. Monomer (PubMed:23707380, PubMed:24722331). Forms a complex with RARG and the SRA1 RNA in the nucleus (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PUS1

tRNA pseudouridine synthase A

PUS1

Molecular Synopsis