FEATURES

FAMILY

DESCRIPTION

Also known as SAR1B_HUMAN, SAR1B, SARA2, SARB. GTP-binding protein involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Activated by the guanine nucleotide exchange factor PREB (By similarity). Involved in the selection of the protein cargo and the assembly of the COPII coat complex (By similarity). Synergizes with the cargo receptor SURF4 to mediate the export of lipoproteins from the endoplasmic reticulum, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis (PubMed:33186557). Homodimer (By similarity). Binds PREB (By similarity). Part of the COPII coat complex (By similarity). Binds to the cytoplasmic tails of target proteins in the endoplasmic reticulum (By similarity). Interacts with SURF4 (PubMed:33186557).

EXTERNAL LINKS

SAR1B

GTP-binding protein SAR1b

SAR1B

Molecular Synopsis