FEATURES

FAMILY

DESCRIPTION

Also known as CCD61_HUMAN, CCDC61. Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker (PubMed:31789463). In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning (PubMed:31789463). During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure (PubMed:30354798). Has been proposed to play a role in CEP170 recruitment to centrosomes (PubMed:30354798). However, this function could not be confirmed (PubMed:31789463). Plays a non-essential role in ciliogenesis (PubMed:31789463, PubMed:32375023). Forms homodimers (via head domain) (PubMed:32375023). Interacts with CEP170 (PubMed:30354798, PubMed:31789463). Interacts with PCM1 and CEP131 (PubMed:31789463). Binds tubulin (PubMed:31789463).

EXTERNAL LINKS

CCDC61

Centrosomal protein CCDC61

CCDC61

Molecular Synopsis