FEATURES

FAMILY

DESCRIPTION

Also known as WASF2_HUMAN, WASF2, WAVE2. Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 (NCKAP1l/HEM1 in hematopoietic cells) and WASF2/WAVE2 (PubMed:16417406). Directly interacts with BRK1. Interacts with FNBP1L (via the SH3 domain) (PubMed:19798448).

EXTERNAL LINKS

WASF2

Wiskott-Aldrich syndrome protein family member 2

WASF2

Molecular Synopsis