FEATURES

DESCRIPTION

Also known as ICOS_HUMAN, ICOS, AILIM. Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). Homodimer; disulfide-linked.

Also known as ICOS_HUMAN, ICOS, AILIM. Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ICOS

Mutations

Mutation(s) distribution

Mutations table