FEATURES

DESCRIPTION

Also known as NS1BP_HUMAN, IVNS1ABP, ARA3, FLARA3, KIAA0850, KLHL39, NS1, NS1BP. Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (PubMed:16582008). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (PubMed:25619834). Inhibits pre-mRNA splicing (in vitro) (PubMed:9696811)., (Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein. Homodimer; through the BTB domain (By similarity). Interacts with AHR/Aryl hydrocarbon receptor (PubMed:16582008). Interacts with HNRNPK (PubMed:23825951). Interacts (via kelch repeats) with KLHL20 (via kelch repeats); this interaction blocks the assembly of Cul3-KLHL20 complex (PubMed:25619834).

Also known as NS1BP_HUMAN, IVNS1ABP, ARA3, FLARA3, KIAA0850, KLHL39, NS1, NS1BP. Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F- ...

EXTERNAL LINKS

IVNS1ABP

Mutations

Mutation(s) distribution

Mutations table